5/16/2023 0 Comments Protein scaffold chromosome![]() ![]() The assembly is scaffolded to chromosome level, providing information on promoters and genes needed for genetic transformation. domesticus and demonstrate how genetics can be used to address limitations in these insects as a food resource. To provide genetic resources to the insect as food industry, we present a reference genome assembly for A. More studies on insect biology in the context of genome sequences are critically important to not only investigate these species while we still can, but also to inspire the world to make greater strides in conserving and preserving biodiversity and natural habitats by demonstrating their value. Coupling genome research and CRISPR/Cas9-mediated genome editing offers an unprecedented potential to rapidly improve insect crops, such as increasing nutritional content, reducing allergenicity, providing resistance to diseases, biomanufacturing, improving feed conversion, increasing growth rate, reducing mortality, and other attributes desired by farmers. The short lifespan and high fecundity of insects offers an opportunity to incorporate genetic modifications rapidly with higher success rates than with larger animals and many plant crops, producing not only food but bioproduction of other valuable materials, such as vaccine antigens. Food and agricultural systems have benefitted from sequencing, with genetic engineering of crops playing a critical role. Not only is sequencing more affordable, improvements in long read length and accuracy as well as scaffolding technology have resulted in near complete genome assemblies, often assembled to chromosomal level. Drosophila melanogaster was one of the first model organisms with a reference genome assembly. Insect genomes are critical to all fields of biological science, from medicine to agriculture and conservation. Mass produced insects can contribute positively to sustainable human existence but require the development of genetic resources. Unfortunately, expanding the amount of land used for livestock production is neither feasible nor sustainable. Global market demand for protein is projected to increase to $32.56 billion by 2028. Nearly half of land on earth is used for agriculture, and at least 70% of agricultural land (30% of the land on earth) is used for livestock. Population increases and scarcity of natural resources and food will lead to conflict around the world. Climate change, reduced productivity of agricultural lands, overfishing, dwindling freshwater, pollution from fertilizers and pesticides, and a host of other factors resulting from population increase will place a disproportionate burden on Earth’s ecosphere. The UN expects the human population to grow to nearly 10 billion by 2050, and food demand is projected to increase up to 62%. With historic levels of biodiversity loss and an increasing human population, it is critical to reduce the consumption of natural resources from earth and its ecosphere. Threats to biodiversity are also threats to all life on earth, including humans. Multiple reports demonstrate that the destruction of natural habitats and pollution from human activity, largely a result of land clearing for agriculture and climate change, have led to substantial global biodiversity loss and mass extinction. Conclusions: We are utilizing these data to develop technologies for downstream commercial applications, including more nutritious and disease-resistant crickets, as well as lines producing valuable bioproducts, such as vaccines and antibiotics. RNAi was demonstrated to disrupt the function of the vermilion eye-color gene producing a useful white-eye biomarker phenotype. domesticus and discuss implications for the food, pharmaceutical, and other industries. We demonstrate both CRISPR/Cas9-mediated knock-in and knock-out of A. domesticus assembly, including Invertebrate Iridescent Virus 6 (IIV6), were submitted as host-associated sequences. Results: Gene groups related to immunity were annotated and will be useful for improving value to insect farmers. domesticus from long read data and scaffolded to chromosome level, providing information needed for genetic manipulation. Methods: We present the first high quality annotated genome assembly of A. As with other crops, genetic resources are needed to improve crickets for food and other applications. Edible insects present a promising alternative for protein production amid a plethora of reports on climate change and biodiversity loss largely driven by agriculture. Background: The house cricket, Acheta domesticus, is one of the most farmed insects worldwide and the foundation of an emerging industry using insects as a sustainable food source. ![]()
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